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1

Drug delivery across the blood–brain barrier: why is it difficult? how to measure and improve it?

Su, Yaming, Sinko, Patrick J

Journal:

Expert Opinion on Drug Delivery

Year:

2006

Language:

english

File:

PDF, 266 KB

english, 2006

2

A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: a new biomaterial for protein drug delivery

Bo Qiu, Simon Stefanos, Jianglin Ma, Anita Lalloo, Barbara A. Perry, Michael J. Leibowitz, Patrick J. Sinko, Stanley Stein

Journal:

Year:

2003

Language:

english

File:

PDF, 258 KB

english, 2003

3

Pharmaceutical and Toxicological Properties of Engineered Nanomaterials for Drug Delivery

Palombo, Matthew, Deshmukh, Manjeet, Myers, Daniel, Gao, Jieming, Szekely, Zoltan, Sinko, Patrick J.

Journal:

Annual Review of Pharmacology

Year:

2014

Language:

english

File:

PDF, 844 KB

english, 2014

4

Carrier-mediated intestinal absorption of valacyclovir, the L-valyl ester prodrug of acyclovir. 1. Interactions with peptides, organic anions and organic cations in rats

Patrick J. Sinko, Praveen V. Balimane

Journal:

Biopharmaceutics & Drug Disposition

Year:

1998

Language:

english

File:

PDF, 207 KB

english, 1998

5

Effect of ionization on the variable uptake of valacyclovir via the human intestinal peptide transporter (hPepT1) in CHO cells

Praveen V. Balimane, Patrick J. Sinko

Journal:

Biopharmaceutics & Drug Disposition

Year:

2000

Language:

english

File:

PDF, 190 KB

english, 2000

6

Nonenzymatic, Self-Elimination Degradation Mechanism of Glutathione

Manjeet Deshmukh, Hilliard Kutscher, Stanley Stein, Patrick Sinko

Journal:

Chemistry & Biodiversity

Year:

2009

Language:

english

File:

PDF, 803 KB

english, 2009

7

Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanism

Manjeet Deshmukh, Yashveer Singh, Simi Gunaseelan, Dayuan Gao, Stanley Stein, Patrick J. Sinko

Journal:

Year:

2010

Language:

english

File:

PDF, 1.59 MB

english, 2010

8

Influence of the microporous substratum and hydrodynamics on resistances to drug transport in cell culture systems: Calculation of intrinsic transport parameters

Hongshi Yu, Patrick J. Sinko

Journal:

Journal of Pharmaceutical Sciences

Year:

1997

Language:

english

File:

PDF, 320 KB

english, 1997

9

Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach

Patrick J. Sinko, Glen D. Leesman, Gordon L. Amidon

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 1.65 MB

1991

10

Recent Trends in Targeted Anticancer Prodrug and Conjugate Design

Singh, Yashveer, Palombo, Matthew, Sinko, Patrick

Journal:

Current Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 765 KB

english, 2008

11

The Architecture and Function of Monoclonal Antibody-Functionalized Mesoporous Silica Nanoparticles Loaded with Mifepristone: Repurposing Abortifacient for Cancer Metastatic Chemoprevention

Gao, Yu, Gu, Songen, Zhang, Yingying, Xie, Xiaodong, Yu, Ting, Lu, Yusheng, Zhu, Yewei, Chen, Wenge, Zhang, Huijuan, Dong, Haiyan, Sinko, Patrick J., Jia, Lee

Journal:

Year:

2016

Language:

english

File:

PDF, 10.26 MB

english, 2016

12

Formulation Predictive Dissolution (fPD) Testing to Advance Oral Drug Product Development: an Introduction to the US FDA Funded ‘21 st Century BA/BE’ Project

Hens, Bart, Sinko, Patrick, Job, Nicholas, Dean, Meagan, Al-Gousous, Jozef, Salehi, Niloufar, Ziff, Robert M., Tsume, Yasuhiro, Bermejo, Marival, Paixão, Paulo, Brasseur, James G., Yu, Alex, Talattof,

Journal:

International Journal of Pharmaceutics

Year:

2018

Language:

english

File:

PDF, 1.38 MB

english, 2018

13

Using novobiocin as a specific inhibitor of breast cancer resistant protein to assess the role of transporter in the absorption and disposition of topotecan

Su, Yaming, Hu, Peidi, Lee, Sung-Hack, Sinko, Patrick J

Journal:

Journal of Pharmacy and Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 763 KB

english, 2007

14

Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin

Daniel A. Norris, Patrick J. Sinko

Journal:

Journal of Applied Polymer Science

Year:

1997

Language:

english

File:

PDF, 289 KB

english, 1997

15

Oral absorption of anti- AIDS nucleoside analogues. 3. Regional absorption and in vivo permeability of 2′, 3′ - dideoxyinosine in an intestinal–vascular access port (IVAP) dog model

Patrick J. Sinko, John P. Sutyak, Glen D. Leesman, Peidi Hu, Vijaya D. Makhey, Hongshi Yu, Curtis L. Smith

Journal:

Biopharmaceutics & Drug Disposition

Year:

1997

Language:

english

File:

PDF, 389 KB

english, 1997

16

Active efflux kinetics of etoposide from rabbit small intestine and colon

Jeevan Kunta, Jiansheng Yan, Vijaya D. Makhey, Patrick J. Sinko

Journal:

Biopharmaceutics & Drug Disposition

Year:

2000

Language:

english

File:

PDF, 186 KB

english, 2000

17

The effect of cell culture conditions on saquinavir transport through, and interactions with, MDCKII cells overexpressing hMDR1

Gregory C. Williams, Gregory T. Knipp, Patrick J. Sinko

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 222 KB

english, 2003

18

Characterization of the oral absorption of β-lactam antibiotics II: Competitive absorption and peptide carrier specificity

Patrick J. Sinko, Gordon L. Amidon

Journal:

Journal of Pharmaceutical Sciences

Year:

1989

Language:

english

File:

PDF, 541 KB

english, 1989

19

Characterization of the oral absorption of some β-lactams: Effect of the α-amino side chain group

Doo-Man Oh, Patrick J. Sinko, Gordon L. Amidon

Journal:

Journal of Pharmaceutical Sciences

Year:

1993

Language:

english

File:

PDF, 431 KB

english, 1993

20

Oral absorption of anti-aids nucleoside analogues. 1. Intestinal transport of didanosine in rat and rabbit preparations

Patrick J. Sinko, Peidi Hu, Anthony P. Waclawski, Nisha R. Patel

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 946 KB

english, 1995

21

Utility of pharmacodynamic measures for assessing the oral bioavailability of peptides. 1. Administration of recombinant salmon calcitonin in rats

Patrick J. Sinko, Curtis L. Smith, Laura T. McWhorter, William Stern, Erik Wagner, James P. Gilligan

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 623 KB

english, 1995

22

Multimeric peptide-based PEG nanocarriers with programmable elimination properties

Simi Gunaseelan, Shahriar Pooyan, Peiming Chen, Mahta Samizadeh, Matthew S. Palombo, Stanley Stein, Xiaoping Zhang, Patrick J. Sinko

Journal:

Year:

2009

Language:

english

File:

PDF, 961 KB

english, 2009

23

Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds

SivaNaga S. Anumolu, Andrea S. DeSantis, Anupa R. Menjoge, Rita A. Hahn, John A. Beloni, Marion K. Gordon, Patrick J. Sinko

Journal:

Year:

2010

Language:

english

File:

PDF, 6.81 MB

english, 2010

24

Enhanced passive pulmonary targeting and retention of PEGylated rigid microparticles in rats

Hilliard L. Kutscher, Piyun Chao, Manjeet Deshmukh, Sujata Sundara Rajan, Yashveer Singh, Peidi Hu, Laurie B. Joseph, Stanley Stein, Debra L. Laskin, Patrick J. Sinko

Journal:

International Journal of Pharmaceutics

Year:

2010

Language:

english

File:

PDF, 609 KB

english, 2010

25

Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries

SivaNaga S. Anumolu, Anupa R. Menjoge, Manjeet Deshmukh, Donald Gerecke, Stanley Stein, Jeffrey Laskin, Patrick J. Sinko

Journal:

Year:

2011

Language:

english

File:

PDF, 3.71 MB

english, 2011

26

Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects

Li Wan, Xiaoping Zhang, Simi Gunaseelan, Shahriar Pooyan, Olivia Debrah, Michael J Leibowitz, Arnold B Rabson, Stanley Stein, Patrick J Sinko

Journal:

AIDS Research and Therapy

Year:

2006

Language:

english

File:

PDF, 1.77 MB

english, 2006

27

Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethyleneglycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells

Tamara Minko, Pankaj V. Paranjpe, Bo Qiu, Anita Lalloo, Roney Won, Stanley Stein, Patrick J. Sinko

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2002

Language:

english

File:

PDF, 181 KB

english, 2002

28

Peritoneal Macrophage Uptake, Pharmacokinetics and Biodistribution of Macrophage-Targeted PEG-fMLF (N-Formyl-Methionyl-Leucyl-Phenylalanine) Nanocarriers for Improving HIV Drug Delivery

Li Wan, Shahriar Pooyan, Peidi Hu, Michael J. Leibowitz, Stanley Stein, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

2007

Language:

english

File:

PDF, 425 KB

english, 2007

29

The role of crystallinity on differential attachment/proliferation of osteoblasts and fibroblasts on poly (caprolactone-co-glycolide) polymeric surfaces

Helen Cui, Patrick J. Sinko

Journal:

Frontiers of Materials Science

Year:

2012

Language:

english

File:

PDF, 717 KB

english, 2012

30

Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated PathogenGardnerella vaginalis

Katia Sutyak Noll, Patrick J. Sinko, Michael L. Chikindas

Journal:

Probiotics and Antimicrobial Proteins

Year:

2011

Language:

english

File:

PDF, 366 KB

english, 2011

31

Pharmacokinetics of Orally Administered Camptothecins

ELORA GUPTA, VIRAL VYAS, FARHEENA AHMED, PATRICK SINKO, THOMAS COOK, ERIC RUBIN

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 2.65 MB

english, 2000

32

Oxidants and antioxidants in sulfur mustard–induced injury

Jeffrey D. Laskin, Adrienne T. Black, Yi-Hua Jan, Patrick J. Sinko, Ned D. Heindel, Vasanthi Sunil, Diane E. Heck, Debra L. Laskin

Journal:

Annals of the New York Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 154 KB

english, 2010

33

Oral absorption of anti-acquired immune deficiency syndrome nucleoside analogues. 2. Carrier-mediated intestinal transport of stavudine in rat and rabbit preparations

Anthony P. Waclawski, Patrick J. Sinko

Journal:

Journal of Pharmaceutical Sciences

Year:

1996

Language:

english

File:

PDF, 416 KB

english, 1996

34

Regional Differences in Intestinal Spreading and pH Recovery and the Impact on Salmon Calcitonin Absorption in Dogs

Yong-Hee Lee, Barbara A. Perry, John P. Sutyak, William Stern, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 634 KB

english, 2000

35

Targeting the Sodium-Dependent Multivitamin Transporter (SMVT) for Improving the Oral Absorption Properties of a Retro-Inverso Tat Nonapeptide

Srinivasan Ramanathan, Shahriar Pooyan, Stanley Stein, Puttur D. Prasad, Jihong Wang, Michael J. Leibowitz, Vadivel Ganapathy, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 185 KB

english, 2001

36

Characterization of the Regional Intestinal Kinetics of Drug Efflux in Rat and Human Intestine and in Caco-2 Cells

Vijaya D. Makhey, Ailan Guo, Daniel A. Norris, Peidi Hu, Jiansheng Yan, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 693 KB

1998

37

Evidence for Diminished Functional Expression of Intestinal Transporters in Caco-2 Cell Monolayers at High Passages

Hongshi Yu, Thomas J. Cook, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 507 KB

1997

38

Differentiation of Gut and Hepatic First-Pass Effect of Drugs: 1. Studies of Verapamil in Ported Dogs

Yong-Hee Lee, Barbara A. Perry, Hee-Sang Lee, Jeevan R. Kunta, John P. Sutyak, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 214 KB

english, 2001

39

Impact of Regional Intestinal pH Modulation on Absorption of Peptide Drugs: Oral Absorption Studies of Salmon Calcitonin in Beagle Dogs

Yong-Hee Lee, Barbara A. Perry, Stacy Labruno, HeeSang Lee, William Stern, Lisa M. Falzone, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.25 MB

1999

40

Intestinal Absorption of Peptides and Peptide Analogues: Implications of Fasting Pancreatic Serine Protease Levels and pH on the Extent of Oral Absorption in Dogs and Humans

Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

1992

File:

PDF, 1.03 MB

1992

41

Determining Intestinal Metabolism and Permeability for Several Compounds in Rats. Implications on Regional Bioavailability in Humans

Patrick J. Sinko, Peidi Hu

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.05 MB

1996

42

Biopharmaceutical Approaches for Developing and Assessing Oral Peptide Delivery Strategies and Systems: In Vitro Permeability and In Vivo Oral Absorption of Salmon Calcitonin

Patrick J. Sinko, Yong-Hee Lee, Vijaya Makhey, Glen D. Leesman, John P. Sutyak, Hongshi Yu, Barbara Perry, Curtis L. Smith, Peidi Hu, Erik J. Wagner, Lisa M. Falzone, Laura T. McWhorter, James P. Gill

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.32 MB

1999

43

Mass Balance Approaches for Estimating the Intestinal Absorption and Metabolism of Peptides and Analogues: Theoretical Development and Applications

Patrick J. Sinko, Glen D. Leesman, Gordon L. Amidon

Journal:

Pharmaceutical Research

Year:

1993

File:

PDF, 854 KB

1993

44

Computation of Log BB Values for Compounds Transported Through Carrier-Mediated Mechanisms Usingin VitroPermeability Data from Brain Microvessel Endothelial Cell (BMEC) Monolayers

Helen H. Usansky, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

2003

Language:

english

File:

PDF, 106 KB

english, 2003

45

Pharmacokinetic Studies in Tg.AC and FVB Mice Administered [14C]Benzene either by Oral Gavage or Intradermal Injection

Matthew J. Hoffmann, Patrick J. Sinko, Yong-Hee Lee, Robert J. Meeker, Robert Snyder

Journal:

Toxicology and Applied Pharmacology

Year:

2001

Language:

english

File:

PDF, 87 KB

english, 2001

46

Characterization of the oral absorption of several aminopenicillins: Determination of intrinsic membrane absorption parameters in the rat intestine in situ

Doo-Man Oh, Patrick J. Sinko, Gordon L. Amidon

Journal:

International Journal of Pharmaceutics

Year:

1992

Language:

english

File:

PDF, 665 KB

english, 1992

47

Site-specific oral absorption of didanosine: in situ characterization and correlation with extent of absorption in vivo

Patrick J. Sinko, Nisha R. Patel, Peidi Hu

Journal:

International Journal of Pharmaceutics

Year:

1994

Language:

english

File:

PDF, 983 KB

english, 1994

48

Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugs

Simi Gunaseelan, Krishnan Gunaseelan, Manjeet Deshmukh, Xiaoping Zhang, Patrick J. Sinko

Journal:

Advanced Drug Delivery Reviews

Year:

2010

Language:

english

File:

PDF, 800 KB

english, 2010

49

Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer

Kyoung-Jin Lee, Nikole Johnson, Jesus Castelo, Patrick J. Sinko, George Grass, Kevin Holme, Yong-Hee Lee

Journal:

European Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 402 KB

english, 2005

50

Preface

Joseph W. Polli, Patrick Sinko

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 63 KB

english, 2006

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